• Benefits - Metabolism
  • Healthy - Blood Sugar Balance
  • Helps Maintain - Blood Pressure
  • Normal - Immunity
  • Positive -Intestinal Function
  • Promotes -Healthy Microbiome 
  • Supports - Cardiovascular Health 

Berberine is an alkaloid found in many plants, but most notably in Goldenseal, Barberry, Oregon grape, and Goldthread. These plants have a long history of use in supporting our health in a variety of ways.* Berberine can be produced from various plant parts (e.g., seed, bark, root, etc.). Enzymedica’s Berberine is unique because it is a completely renewable and sustainable product produced from the seeds of barberry and uses a targeted delivery capsule to prevent the breakdown of the capsule and early release of berberine in the stomach. This type of capsule is recommended for proper berberine supplementation. In an acidic environment berberine binds with other berberine molecules to form insoluble complexes that do not get absorbed. 

Berberine has been extensively studied in clinical trials for positively influencing regular blood sugar, lipids, and hypertension.*

Berberine has also been examined as a weight loss aid in two double-blind clinical trials.*

In one study, 37 men and women with metabolic syndrome were given 300 mg of berberine three times per day for three months. The body mass index (BMI) levels dropped from 31.5 to 27.4.(2)*

In another study, 500 mg of berberine three times per day caused an average of 5 pounds of weight loss over a 12-week period.(3)*

Recommended Use: One 500 mg capsule before meals with a glass of water two to three times daily.


Berberine and berberine-containing plants are not recommended for use during pregnancy.

Berberine may interfere with the absorption of tetracycline and related antibiotics. Berberine produces significant inhibition of CYP3A enzymes in humans. Because these enzymes metabolize most drugs, berberine may decrease the clearance of many medications thereby potentiating their effect.

Berberine-containing plants may enhance the effects of oral hypoglycemic drugs through its multitude of anti-diabetic effects. People on oral hypoglycemic drugs should monitor blood glucose levels if taking berberine. Adjustment of drug dosage may be required.

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